|
Infection |
IV treatment |
Oral treatment |
Total duration |
|
Herpes simplex (genital) |
Aciclovir 200mg qds, increase to 400mg qds if absorption impaired |
5 days |
|
|
Varicella |
If severe |
Aciclovir 800mg five times a day |
7 days |
|
Herpes zoster |
If severe |
Aciclovir 800mg five times a day |
7 days |
|
Herpes simplex virus encephalitis |
Aciclovir 10mg/kg tds |
10 days |
Immunocompromised patients
|
Infection |
IV treatment |
Oral treatment |
Total duration |
|
Herpes simplex (prophylaxis) |
. |
Aciclovir 200-400mg qds orally |
|
|
Herpes simplex |
. |
Aciclovir 400mg qds |
5 days |
|
Severe / genital |
Aciclovir 5mg/kg tds* |
. |
|
|
Varicella and |
If severe 5mg/kg tds* |
Aciclovir 800mg five times a day |
7 days |
|
Herpes simplex |
10mg/kg tds* |
10 days |
NOTES:
*For patients with renal impairment refer to section 23 for dosage adjustments
For obese patients calculate the
dose of aciclovir on lean (ideal) body weight
Consult a microbiologist/virologist
in the case of severe HSV or VZV disease.
Calculation of lean body weight
Lean body weight = sex factor + {2.3 x inches over 5 foot}
Sex factor = 50kg for a man, 45kg for a women